Research Core 1 - Clinical and Translational Research Methods


CORE LEADERS

Richard Macko, M.D., Co-Leader
Telephone: 410-605-7063|
E-mail: rmacko@grecc.uaryland.edu

Jay Magaziner, Ph.D., M.S.Hyg. Co-Leader
Telephone: 410-706-3553|
E-mail: jmagazin@epi.umaryland.edu



OVERVIEW
The mission of the Clinical and Translational Research Methods Core is to design, implement, and evaluate clinical and translational research in exercise rehabilitation and recovery in older patients with stroke, hip fracture, and other medical conditions associated with functional limitations in aging. The core has been organized into two levels of translation: bench to clinical laboratory; and clinical laboratory to community.

Increasing collaborations represented by dual core leadership provide a translational research model that focuses on the following aims:

1.  Facilitate the design and conduct of research investigating mechanisms underlying the neuromuscular, cardiovascular, functional and behavioral limitations associated with stroke, hip fracture and other chronic disabling diseases in older people:

A. Determine the disability phenotype.

B. Identify phenotypic changes that occur as older people recover from disabling conditions.

C.  Evaluate predictors of recovery and functional decline.

D.  Evaluate efficacy of disability-specific exercise and motor learning rehabilitation interventions.

2.  Translate efficacious exercise interventions into community programs:

A.  Evaluate the factors that impede or facilitate the conduct of rehabilitation interventions.

3.  Provide a forum for scientists interested in the recovery process to discuss new developments in this area.